18Feb 2017

HEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA ON DIABETIC MICE.

  • Department of Biotechnology, L. N. Mithila University, Darbhanga.
  • Research Centre, Mahavir Cancer Sansthan and Research Centre, Patna.
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Diabetes mellitus is a major health problem for the people of the world. Diabetes is a chronic metabolic disorder resulting from a variable interaction of hereditary and environmental factors and it is characterized by abnormal insulin secretion or insulin receptor affecting ? cells of pancreas. Itis associated with a number of chronic complications including nephropathy, neuropathy, retinopathy and cardiovascular diseases. Diabetes mellitus affects a large number of people throughout the world and India also. Experts estimate that diabetic population will grow from 195 to 360 million by 2030 almost 4.5 percentage of the global population. Present study included histological and biochemical parameters of mice. Three groups of mice were prepared for comparative study on control, diabetic, and N. sativa .Diabetic models were prepared in mice by intraperitoneal administration of single dose of alloxan@120mg/kg b.w. Alcoholic extract of Nigella sativa was administered @100 mg/kg b.w/day for four and eight weeks. In diabetic group of mice glucose, creatinine, urea and SGPT were increased. Effective restoration was observed in glucose, SGPT, urea and createnine of N. sativa administered diabetic group of mice. Liver also shows effective restoration in N. sativa administered group of mice. Thus, it is concluded from study that alcoholic extract of N.sativa restores glucose level to normal. Nigella sativa acts effectively on diabetes mice on biochemical and histological parameters.

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[Sneha Navin, Jaykar Jha, Abhinav, Arun Kumar, Mohammad Ali, Ashok Ghosh and Ranjit Kumar. (2017); HEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA ON DIABETIC MICE. Int. J. of Adv. Res. 5 (Feb). 181-188] (ISSN 2320-5407). www.journalijar.com

Dr Ranjit Kumar
Mahavir Cancer Institute and Research Centre, Patna, Bihar, India

DOI:

Article DOI: 10.21474/IJAR01/3130      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3130

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